Or Kakhlon Selected Research

Adult Form Polyglucosan Body Disease

10/2021	Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism.
1/2018	Guaiacol as a drug candidate for treating adult polyglucosan body disease.
10/2015	Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
4/2015	Deep intronic GBE1 mutation in manifesting heterozygous patients with adult polyglucosan body disease.
10/2013	Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase.

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Or Kakhlon Research Topics

Disease

5	Adult Form Polyglucosan Body Disease 10/2021 - 10/2013
3	Neoplasms (Cancer) 01/2022 - 01/2019
2	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2019
2	Glycogen Storage Disease Type IV (Andersen's Disease) 10/2015 - 10/2013
2	Muscular Diseases (Myopathy) 01/2015 - 01/2015
2	Glycogen Storage Disease Type II (Pompe's Disease) 01/2015 - 01/2015
2	X-linked sideroblastic anemia 03/2010 - 12/2008
2	Anemia 03/2010 - 12/2008
2	Ataxia (Dyssynergia) 03/2010 - 12/2008
2	Chronic Disease (Chronic Diseases) 03/2010 - 12/2008
2	Friedreich Ataxia (Friedreich's Ataxia) 03/2010 - 12/2008
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 10/2021
1	Burns 10/2021
1	Iron Deficiencies 01/2021
1	Carcinoma (Carcinomatosis) 01/2019
1	Late Onset Disorders 01/2018
1	Lower Urinary Tract Symptoms 10/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2015
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 04/2014
1	Gaucher Disease (Gaucher's Disease) 04/2014
1	Starvation 10/2013
1	Glycogen Storage Disease (Glycogenosis) 10/2013
1	sideroblastic spinocerebellar ataxia Anemia 03/2010
1	Iron Overload 03/2010
1	Hypersensitivity (Allergy) 12/2008

Drug/Important Bio-Agent (IBA)

4	Adenosine Triphosphate (ATP)IBA 01/2022 - 12/2008
3	GlycogenIBA 10/2021 - 10/2013
3	polyglucosanIBA 10/2021 - 10/2013
3	IronIBA 01/2021 - 12/2008
3	1,4-alpha-Glucan Branching Enzyme (Glycogen Branching Enzyme)IBA 01/2018 - 10/2013
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 01/2019
2	Pharmaceutical PreparationsIBA 01/2018 - 03/2010
2	EnzymesIBA 01/2015 - 04/2014
2	DeferiproneIBA 03/2010 - 12/2008
2	FrataxinIBA 03/2010 - 12/2008
2	SiderophoresIBA 03/2010 - 12/2008
1	Membrane LipidsIBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	2-hydroxyoleic acidIBA 01/2022
1	CarbohydratesIBA 10/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	2-hydroxy-9-cis-octadecenoic acidIBA 01/2019
1	GuaiacolIBA 01/2018
1	Peptides (Polypeptides)IBA 10/2015
1	CaspasesIBA 01/2015
1	GlucosidasesIBA 01/2015
1	CalciumIBA 01/2015
1	AcidsIBA 01/2015
1	Lysergic Acid Diethylamide (LSD)IBA 01/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015
1	Glucosylceramidase (Glucocerebrosidase)IBA 04/2014
1	Vinblastine (Vinblastine Sulfate)FDA Link 10/2013
1	Small Interfering RNA (siRNA)IBA 10/2013
1	Sirolimus (Rapamycin)FDA Link 10/2013
1	Glycogen Synthase (Synthase I)IBA 10/2013
1	Chelating AgentsIBA 03/2010
1	Isoflurophate (DFP)FDA Link 03/2010
1	StaurosporineIBA 12/2008
1	Mitochondrial DNA (mtDNA)IBA 12/2008

Therapy/Procedure

3	Therapeutics 01/2022 - 10/2021
1	Prostatectomy (Retropubic Prostatectomy) 10/2015